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Personal Information  
Name :Ahlam Zaid Alkilani
Academic Rank :Assistant Professor
Office No :1998
Phone :
Department :Pharmacy
Email :ahlamk@zu.edu.jo

Research - Journals
Donnelly, R. F., Morrow, D. I., McCrudden, M. T., Alkilani, A. Z., Vicente‐Pérez, E. M., O'Mahony, C., ... & Woolfson, A. D. , Hydrogel-Forming and Dissolving Microneedles for Enhanced Delivery of Photosensitizers and Precursors, Photochemistry and Photobiology , 641-647 page.
We present “one-step application” dissolving and hydrogelforming microneedle arrays (MN) for enhanced delivery of photosensitizers/precursors. MN (280 lm) prepared from 20% w/w poly(methylvinylether/maelic acid) and cross-linked with glycerol by esterication to form hydrogels upon skin insertion, or allowed to dissolve rapidly in skin, were combined with patches containing 19 mg cm2 of 5-aminolevulinic acid (ALA) or meso-tetra (N-methyl-4-pyridyl) porphine tetra tosylate (TMP) for drug

Donnelly, R. F., Singh, T. R. R., Alkilani, A. Z., McCrudden, M. T., O’Neill, S., O’Mahony, C.& Woolfson, A. D. , Hydrogel-forming microneedle arrays exhibit antimicrobial properties: Potential for enhanced patient safety., International journal of pharmaceutics , page 76-91
We describe, for the first time, the microbial characterisation of hydrogel-forming polymeric microneedle arrays and the potential for passage of microorganisms into skin following microneedle penetration. Uniquely, we also present insights into the storage stability of these hydroscopic formulations, from physical and microbiological viewpoints, and examine clinical performance and safety in human volunteers. Experiments employing excised porcine skin and radiolabelled microorganisms showed tha

Donnelly, R. F., Moffatt, K., Alkilani, A. Z., Vicente-Pérez, E. M., Barry, J., McCrudden, M. T., & Woolfson, A. D , Hydrogel-forming microneedle arrays can be effectively inserted in skin by self-application: A pilot study centred on pharmacist intervention and a patient information leaflet., Pharmaceutical research , page 1-11
Purpose To investigate, for the first time, the influence of pharmacist intervention and the use of a patient information leaflet on self-application of hydrogel-forming microneedle arrays by human volunteers without the aid of an applicator device. Methods A patient information leaflet was drafted and pharmacist counselling strategy devised. Twenty human volunteers applied 11 × 11 arrays of 400 μm hydrogel-forming microneedle arrays to their own skin following the instructions provided. Skin

Ahlam Zaid Alkilani , Design and physicochemical characterisation of novel dissolving polymeric microneedle arrays for transdermal delivery of high dose, low molecular weight drugs, Journal of Controlled Release , page 71-80
We describe formulation and evaluation of novel dissolving polymeric microneedle (MN) arrays for the facilitated delivery of low molecular weight, high dose drugs. Ibuprofen sodium was used as the model here and was successfully formulated at approximately 50% w/w in the dry state using the copolymer poly(methylvinylether/maleic acid). These MNs were robust and effectively penetrated skin in vitro, dissolving rapidly to deliver the incorporated drug. The delivery of 1.5 mg ibuprofen sodium, the

Ahlam Zaid Alkilani , Microneedle-Iontophoresis Combinations for Enhanced Transdermal Drug Delivery, Drug Delivery System , chapter 121-131
t has recently been proposed that the combination of skin barrier impairment using microneedles (MNs) coupled with iontophoresis (ITP) may broaden the range of drugs suitable for transdermal delivery as well as enabling the rate of delivery to be achieved with precise electronic control. However, few reports exist on the combination of ITP with in situ drug-loaded polymeric MN delivery systems. Our in vitro permeation studies revealed that MN enhances transdermal drug delivery. The combination o

, Ahlam Zaid Alkilani, ,
The skin offers an accessible and convenient site for the administration of medications. To this end, the field of transdermal drug delivery, aimed at developing safe and efficacious means of delivering medications across the skin, has in the past and continues to garner much time and investment with the continuous advancement of new and innovative approaches. This review details the progress and current status of the transdermal drug delivery field and describes numerous pharmaceutical developm
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Hydrogel microneedle array assisted iontophoretic transdermal delivery of a model protein
UKICRS Symposium
Belfast. UK
Skin is an appealing site for systemic delivery of active pharmaceutical ingredients [1]. However, the stratum corneum, which is the outermost layer of the sk

Optical Coherence Tomographic characterization of skin insertion of polymeric microneedle loaded with ovalbumin
International Conference on Microneedles
Cork, Ireland
Skin is an appealing site for systemic delivery of active pharmaceutical ingredients [1]. However, the stratum corneum which is the mostouter layer of the skin acts as the principal barrier for penetration of most drugs. For this reason, microneedle

Influence of polymer concentration, crosslinker molecular weight and swelling conditions upon the diffusion parameter of polyethylene glycol – crosslinked poly (methyl vinyl ether-co-maleic acid) film
.Stratum Corneum VIII Conference,
Cardiff .UK
In the permeation studies with ibuprofen sodium and ovalbumin side-by-side type diffusion cells were used. These consist of donor and receptor half-cells. A w